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1

DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest

Zhicong He, Xianyong Bu, Alexandra Eleftheriou, Malik Zihlif, Zhang Qing, Bernard W. Stewart, Laurence P.G. Wakelin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 560 KB

english, 2008

2

Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N -(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG) 2 at 1.3-Å Resolution

Todd, Alan K., Adams, Adrienne, Thorpe, James H., Denny, William A., Wakelin, Laurence P. G., Cardin, Christine J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 212 KB

english, 1999

3

α-CycloPNA: 1-Aminocylopentane-1-carboxylic Acid-Derived Peptide Nucleic Acid

Nicola M. Howarth, Laurence P. G. Wakelin, David M. Walker

Journal:

Year:

2004

File:

PDF, 58 KB

2004

4

Polyfunctional DNA intercalating agents

Laurence P. G. Wakelin

Journal:

Medicinal Research Reviews

Year:

1986

Language:

english

File:

PDF, 3.96 MB

english, 1986

5

NMR study of substituent effects in platinum(II) intercalating agents

Robert T. C. Brownlee, W. David McFadyen, Maxwell J. O'Connor, Trevor J. Rook, Ian A. G. Roos, Laurence P. G. Wakelin

Journal:

Magnetic Resonance in Chemistry

Year:

1987

Language:

english

File:

PDF, 517 KB

english, 1987

6

Collection and analysis of kinetic data from a stopped-flow spectrophotometer using a microcomputer

Ian A.G. Roos, Laurence P.G. Wakelin, John Hakkennes, John Coles

Journal:

Analytical Biochemistry

Year:

1985

Language:

english

File:

PDF, 2.49 MB

english, 1985

7

Interaction of phenosafranine with nucleic acids and model polyphosphates: II. Characterisation of phenosafranine binding to DNA

Zdenka Balcarová, Vladimír Kleinwächter, Jaromír Koudelka, Günter Löber, Karl-Ernst Reinert, Laurence P.G. Wakelin, Michael J. Waring

Journal:

Biophysical Chemistry

Year:

1978

Language:

english

File:

PDF, 1.45 MB

english, 1978

8

Interaction of paired homologous series of diacridines and triacridines with deoxyribonucleic acid

William A. Denny, Graham J. Atwell, Gayle A. Willmott, Laurence P.G. Wakelin

Journal:

Biophysical Chemistry

Year:

1985

Language:

english

File:

PDF, 862 KB

english, 1985

9

DNA threading agents: effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides

Mark Searcey, P. Noel Martin, Nicola M. Howarth, Bernie Madden, Laurence P.G. Wakelin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

10

Synthesis of the four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid

Nicola M. Howarth, Laurence P.G. Wakelin, David M. Walker

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

11

Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells

Steven J Wolf, Tony Huynh, Nicole S Bryce, Trevor W Hambley, Laurence PG Wakelin, Bernard W Stewart, Daniel R Catchpoole

Journal:

BMC Cell Biology

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

12

In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines

Steven J. Wolf, Laurence P. G. Wakelin, Zhicong He, Bernard W. Stewart, Daniel R. Catchpoole

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 537 KB

english, 2009

13

Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability

Gourdie, Trudi A., Prakash, A. S., Wakelin, Laurence P. G., Woodgate, Paul D., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 2.21 MB

english, 1991

14

DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain

Valu, Kisione K., Gourdie, Trudi A., Boritzki, Theodore J., Gravatt, G. Lance, Baguley, Bruce C., Wilson, William R., Wakelin, Laurence P. G., Woodgate, Paul D., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 883 KB

english, 1990

15

Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity

Denny, William A., Atwell, Graham J., Baguley, Bruce C., Wakelin, Laurence P. G.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 994 KB

english, 1985

16

[Co(III)(cyclen)Cl2]Cl is selectively cytotoxic to human leukaemia cells

Zhicong He, Donna Lai, Laurence P.G. Wakelin

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 263 KB

english, 2010

17

DNA-binding compounds – synthesis and intercalating properties of a peptide-diamino diacridine

DAVID P. KELLY, PHILIP O-L. MACK, ROGER F. MARTIN, LAURENCE P.G. WAKELIN

Journal:

Chemical Biology & Drug Design

Year:

1985

Language:

english

File:

PDF, 446 KB

english, 1985

18

Didemnin B Conformation and dynamics of an antitumour and antiviral depsipeptide studied in solution by 1H and 13C. n.m.r. spectroscopy

MARK S. SEARLE, JON G. HALL, ILIAS KYRATZIS, LAURENCE P.G. WAKELIN

Journal:

Chemical Biology & Drug Design

Year:

1989

Language:

english

File:

PDF, 886 KB

english, 1989

19

Differences between central and peripheral rat α-adrenoceptors revealed using binuclear ligands

Adrienne Adams, Bevyn Jarrott, William A. Denny, Laurence P.G. Wakelin

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 648 KB

english, 1986

20

Alkyl-linked diquinolines are monofunctional AT-selective DNA-intercalating agents

W.David McFadyen, William A. Denny, Laurence P.G. Wakelin

Journal:

Year:

1988

Language:

english

File:

PDF, 580 KB

english, 1988

21

Structural Characterisation of Bisintercalation in Higher-order DNA at a Junction-like Quadruplex

Susana C.M. Teixeira, James H. Thorpe, Alan K. Todd, Harold R. Powell, Adrienne Adams, Laurence P.G. Wakelin, William A. Denny, Christine J. Cardin

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 1.16 MB

english, 2002

22

The interaction of substituted and rigidly linked diquinolines with DNA

W.David McFadyen, N. Sotirellis, William A. Denny, Laurence P.G. Wakelin

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1990

Language:

english

File:

PDF, 645 KB

english, 1990

23

Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H-NMR spectroscopy

Mark S. Searle, Laurence P.G. Wakelin

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1990

Language:

english

File:

PDF, 829 KB

english, 1990

24

DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard

Gourdie, Trudi A., Valu, Kisione K., Gravatt, G. Lance, Boritzki, Theodore J., Baguley, Bruce C., Wakelin, Laurence P. G., Wilson, William R., Woodgate, Paul D., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.47 MB

english, 1990

25

α1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length

Chen, Junli, Murad, Ahsan K., Wakelin, Laurence P.G., Denny, William A., Griffith, Renate, Finch, Angela M.

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

26

In vitro and in vivo studies of neutral cyclometallated complexes against murine leukæmias

Edwards, Gavin L, Black, David St.C, Deacon, Glen B, Wakelin, Laurence PG

Journal:

Canadian Journal of Chemistry

Year:

2005

Language:

english

File:

PDF, 181 KB

english, 2005

27

Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents

Edwards, Gavin L, Black, David St.C, Deacon, Glen B, Wakelin, Laurence PG

Journal:

Canadian Journal of Chemistry

Year:

2005

File:

PDF, 188 KB

2005

28

Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA intercalating agents which bind by threading through the DNA helix

Wakelin, Laurence P. G., Chetcuti, Pat, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 793 KB

english, 1990

29

Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents

Wakelin, Laurence P. G., Atwell, Graham J., Rewcastle, Gordon W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1004 KB

english, 1987

30

Activity of platinum(II) intercalating agents against murine leukemia L1210

McFadyen, W. David, Wakelin, Laurence P. G., Roos, Ian A. G., Leopold, Virginia A.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 569 KB

english, 1985

31

DNA-binding properties and antitumour activity of monofunctional alkylating groups attached to the DNA-intercalating chromophore phenanthridine: n-bromoalkylphenanthridinium bromides

Wickham, Geoffrey, Prakash, A.S., Wakelin, Laurence P.G., McFadyen, W. David

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1991

Language:

english

File:

PDF, 621 KB

english, 1991

32

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines

Peter B. Roberts, William A. Denny, Laurence P. G. Wakelin, Robert F. Anderson and William R. Wilson

Journal:

Radiation Research

Year:

1990

Language:

english

File:

PDF, 635 KB

english, 1990

33

Kinetics of the interaction between echinomycin and deoxyribonucleic acid

Fox, Keith R., Wakelin, Laurence P. G., Waring, Michael J.

Journal:

Year:

1981

Language:

english

File:

PDF, 1.43 MB

english, 1981

34

NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5'-GCATGC)2

Searle, Mark S., Hall, Jon G., Denny, William A., Wakelin, Laurence P. G.

Journal:

Year:

1988

Language:

english

File:

PDF, 1.12 MB

english, 1988

35

Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged Chromophores

Wakelin, Laurence P. G., Adams, Adrienne, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

36

Crystal Structure of the Topoisomerase II Poison 9-Amino-[ N -(2-dimethylamino)ethyl]acridine-4-carboxamide Bound to the DNA Hexanucleotide d(CGTACG) 2†

Adams, Adrienne, Guss, J. Mitchell, Collyer, Charles A., Denny, William A., Wakelin, Laurence P. G.

Journal:

Year:

1999

Language:

english

File:

PDF, 214 KB

english, 1999

37

cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity

Webster, Lorraine K., Deacon, Glen B., Buxton, David P., Hillcoat, Brian L., James, Alison M., Roos, Ian A. G., Thomson, Robin J., Wakelin, Laurence P. G., Williams, Tracey L.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 686 KB

english, 1992

38

DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards

Prakash, A. S., Denny, William A., Gourdie, Trudi A., Valu, Kisione K., Woodgate, Paul D., Wakelin, Laurence P. G.

Journal:

Year:

1990

Language:

english

File:

PDF, 5.34 MB

english, 1990

39

N-methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor

Kobylecki, Ryszard J., Lane, Anthony C., Smith, Colin F. C., Wakelin, Laurence P. G., Cruse, William B. T., Egert, Ernst, Kennard, Olga

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 416 KB

english, 1982

40

10.1021/jo974036u

Howarth, Nicola M., Wakelin, Laurence P. G.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 9 KB

english, 2000

41

Bisintercalating Threading Diacridines: Relationships between DNA Binding, Cytotoxicity, and Cell Cycle Arrest

Wakelin, Laurence P. G., Bu, Xianyong, Eleftheriou, Alexandra, Parmar, Alpesh, Hayek, Charbel, Stewart, Bernard W.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

42

Mass Spectrometry Studies of the Binding of the Minor Groove-Directed Alkylating Agent Alkamin to AT-Tract Oligonucleotides

Abdul Majid, Amin M. S., Smythe, George, Denny, William A., Wakelin, Laurence P. G.

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 1.34 MB

english, 2009

43

DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II)

Lee, Ho H., Palmer, Brian D., Baguley, Bruce C., Chin, Michael, McFadyen, W. David, Wickham, Geoffrey, Thorsbourne-Palmer, Deborah, Wakelin, Laurence P. G., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 736 KB

english, 1992

44

α-PNA: A Novel Peptide Nucleic Acid Analogue of DNA

Howarth, Nicola M., Wakelin, Laurence P. G.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 342 KB

english, 1997

45

Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines

Chen, Junli, Campbell, Adrian P., Urmi, Kaniz F., Wakelin, Laurence P.G., Denny, William A., Griffith, Renate, Finch, Angela M.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

46

Bleomycin mimics. Design and synthesis of an acridine derivative which cleaves DNA in a sequence-neutral manner

Searcey, Mark, McClean, Siobhán, Madden, Bernie, Wakelin, Laurence P. G.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Year:

1997

Language:

english

File:

PDF, 716 KB

english, 1997

47

α-cycloPNA: 1-Aminocylopentane-1-carboxylic Acid-Derived Peptide Nucleic Acid

Howarth, Nicola M., Wakelin, Laurence P. G., Walker, David M.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2003

Language:

english

File:

PDF, 185 KB

english, 2003

48

The solution structure of bis(phenazine-1-carboxamide)-DNA complexes: MLN 944 binding corrected and extended

Serobian, Andre, Thomas, Donald S., Ball, Graham E., Denny, William A., Wakelin, Laurence P. G.

Journal:

Year:

2014

Language:

english

File:

PDF, 911 KB

english, 2014

49

Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: an NMR and molecular modelling study

Searle, Mark S., Bicknell, Wendy, Wakelin, Laurence P.G., Denny, William A.

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 888 KB

english, 1991

50

Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening

Drwal, Malgorzata N., Marinello, Jessica, Manzo, Stefano G., Wakelin, Laurence P. G., Capranico, Giovanni, Griffith, Renate, Sem, Daniel S.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.08 MB

english, 2014

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